Outlook 2010 will open only in Safe Mode?
Another broken patch from Microsoft came at us this month. KB3114409 may cause some users to be unable to open Outlook 2010 except in Safe Mode. No custom settings are retained, your views and options will always revert to safe defaults every time you open Outlook.
For now removing KB3114409 from your workstation cures the problems. I suspect MS will re-issue this patch in the next week - so you can either hide the update after removing it (if you have automatic updates this is recommended) or ignore it if your updates are set to manual.
WSUS operators should reject this patch on their corporate networks for now.